I've played RE4. I like it better on PS2 (or emulator) because I'm not getting confused with controls. If you bind buttons on emulator or have game on console you know which button is X or L1. RE4 on PC is total mess if you look at controls. QTE, game says 'press 1 + 2', sure, you press it and die; if you look at controls menu (in separate config utility) there is 1 as aim and 2 as knife, etc. You need to memorize all controls, there is no 'press Q + E' or 'knife + aim', same thing with interaction 'press 3', 3? Oh, Use button...
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And you can always set 1080p in PCSX2.
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Seriously PS2 doesn't have more games similar to RE4?