So Googling the problem, it seems that Dios Mios doesn't actually work with the latest version of USB Loader GX. You'd have to download a beta version. Which I did, tried to play Twin Snakes. This got me past the annoying "Copy the game to your SD card" problem...but the audio on the title screen skips and it locks when either trying to go to the briefing or at the first Codec call. Ugh. I just want to play Twin Snakes from my USB, since the Wii's disk drive is conking out and I'd rather not further abuse it with burned disks.