I'm on an Athlon II X3 435 @ 2.9 GHz and an old 8800GT. It's by no means an extremely powerful PC. That screenshot is from Xenoblade, and it actually runs quite well (full speed most of the time, except when there's a lot going on in a battle) on my rig, but only with the correct settings and only on newer builds. On older versions of Dolphin, I couldn't run it as well as I can now.