Originally Posted by
Prom Night Dumpster Baby
Make sure you're not running a gazillion things in the background.
Speedhacks may be necessary, if they don't corrupt the graphics or cause bugs then leave them on.
As Warrior said consult a wiki for specific game settings. It's a pain in the ass I know but many games run a little differently.
You can try switching from dx9 to 10 or even give software mode a try.
And obviously the more you upscale the more resources you'll need so leave the resolution at native while testing out a game for the first time.
Your PC "should" be enough to run just about everything at full speed at native. Some games still have compatibility issues and won't run well despite any effort but that list is getting smaller all the time so once again consulting a wiki for a game or a compatibility list is a good idea.