Yeah, I know absolutely nothing about LoL so there's that.
The first time I read it, I honestly felt like the sentence was unfinished. Let me give an example:
Oriのultが馬鹿みたいな火力で草
を焼いてる
Ori's ultra is burning up the grass with its ridiculous offensive output. Now, ignore the fact that this might or might not actually be possible in the game, this is just an example.
で can also be used as a connective particle for na-adjectives when listing characteristics, for example その子が乱暴で騒がしいよ, lit. that kid is violent and noisy.
In all honestly since it was just a Tweet anything is possible.
