I'm gonna pass on some of SegNins good advice. Download Deamon tools @ http://www.daemon-tools.cc/dtcc/download.php, install,
mount cd image of the game(left click the Tray icon, click on device 0, and it should bring up a browse window)
make sure that Analog Audio is enabled(right click tray icon, go to options, make sure Analog audio is checked)
then go into ePSXe > File > run from CDROM
I use this a bit so ask for help if you need to.