Every time I load up a save state I get some heavy sound distortion or interference. I've noticed it on two games thus far (out of two played). Chrono Trigger in which it would stop as soon as I entered a battle (I assumed it was the changing of background music but considering the following I'm not sure) and Chrono Cross where it would persist after entering a battle (changing screens didn't work but I don't know about changing areas). A quick test using The Legend of Dragoon didn't get any sound issues.
Here's my specs
Emulator: ePSXe
Sound Plugin: P.E.Op.S. DSound Audio Driver 1.9
BIOS: bios\SCPH1001.BIN
Graphics: P.E.Op.S. Soft Graphics 1.8
Comp Specs:
Windows 7 Professional 64 bit
6gb of RAM
Intel Core Duo 2.5GHz
NVIDIA GeForce GTX 260M
Realtex High Definition Audio
(I can post the dxdiag file if that's not enough)