Far as I can tell this particular game isn't quite 100% compatible yet. You can try opengl software mode (don't forget to set rendering threads to 2 if so!!!) I would turn off the ee and vu speed hacks but leave MTVU on. Might also give EFB copies to ram ticked on as well. Even so it's still going to be a bit buggy.
You can try increasing the EE and vu cycle hacks back up incremently (and test) and hopefully find a balance. The higher you go the more chance of graphics corruption though. Software mode draws from the cpu so can possibly really slow down the game (make sure rendering threads are set to 2 when in software mode!!!!) Making sure all unnecessary background programs are closed too, might give it a bump.